Potentially fatal congestive heart failure chf may occur months to years after completion of therapy. Doxorubicin hydrochloride suitable for fluorescence, 98. Lee et al 2019 extracorporeal shock waves protect cardiomyocytes from doxinduced cardiomyopathy by upregulating survivin via the integrinilkaktsp1p53 axis. Doxorubicin hydrochloride is sparingly soluble in aqueous buffers. Doxorubicin is a naturally occurring anthracycline antibiotic that is an essential component of many treatment regimens for solid and blood tumors, and it is broadly considered the most active single agent available for the treatment. Doxorubicin free base, also called doxorubicin, is an anthracycline antibiotic with antineoplastic activity. Doxorubicin is effective in controlling a wide variety of canine and feline tumors table 15.
Sigma aldrich offers a number of doxorubicin hydrochloride products. However, clinical administration of doxorubicin is limited by offtarget cardiotoxicity, which is thought to be mediated by doxorubicinol, the primary alcohol metabolite of doxorubicin. Doxorubicin pi may 8, 2003 1 1 2 doxorubicin hydrochloride for injection, usp 3 4 doxorubicin hydrochloride injection, usp 5 6 rx only 7 8 for intravenous use only 9 10 warning 11 1. Download product insert pdfdownload safety data sheet sds. In summary, doxorubicin is a very useful chemotherapy drug used in a multitude of diagnoses and is commonly seen in the outpatient setting for the treatment of breast cancer, lymphomas, and leukemias. Doxorubicin, sold under the brand name adriamycin among others, is a chemotherapy medication used to treat cancer.
Doxorubicin hydrochloride for injection, usp doxorubicin. Doxorubicin in combination with adenoviral mnsod admnsod plus 1,3bis2chloroethyl1 nitrosourea bcnu has the greatest effect in decreasing the volumes of mb231 tumors and prolonging survival of mice. Doxorubicin comes as a solution liquid or as a powder to be mixed with liquid to be injected intravenously into a vein by a doctor or nurse in a medical facility. An overview of doxorubicin formulations in cancer therapy article pdf available in journal of cancer research and therapeutics 104. Material safety data sheet msds cell signaling technology. Doxorubicin, isolated from the bacterium streptomyces peucetius var. Doxorubicin was used to induce apoptosis, and to induce. Doxorubicin, hydrochloride salt, 99% lc laboratories. Doxorubicin hydrochloride, topoisomerase ii inhibitor cas 25316409, with 98% purity.
Doxorubicin was excreted in the milk of one lactating patient, with peak milk concentration at 24 hours after treatment being approxi er therapy with 70 mgm. It is often used together with other chemotherapy agents. Doxorubicin hydrochloride is subject to light degradation at 0. Doxorubicin offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Citations are publications that use tocris products. Extreme high moderate low section 1 chemical product and company identification product name doxorubicin hcl adriamycin statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. Doxorubicin intercalates between base pairs in the dna helix, thereby preventing dna replication and ultimately inhibiting protein synthesis. This includes breast cancer, bladder cancer, kaposis sarcoma, lymphoma, and acute lymphocytic leukemia. Severe local tissue necrosis will occur if there is extravasation during administratio. Doxorubicin must not be given by the intramuscular or subcutaneous route. Approved api for cancer therapeutic use doxorubicin hcl.
This agent has earned its infamous nickname, the red devil, based on its bright red koolaid red color, vesicant properties, and sideeffect. Doxorubicin hydrochloride cas 25316409 scbt santa cruz. Comparison of doxorubicin concentration profiles in. Metabolism of doxorubicin to the cardiotoxic metabolite.
Thus, our study has reduced the effect of publication bias. The intercalation into dna blocks the replication of dna by blocking topo ii topoisomerase ii. Doxorubicin in combination with adenoviral mnsod admnsod plus 1,3bis2chloroethyl1nitrosourea bcnu has the greatest effect in decreasing the volumes of mb231 tumors and prolonging survival of mice. Join researchers using our high quality biochemicals. Doxorubicin, an anthracycline antibiotic, inhibits dna and rna synthesis in mammalian cells and has been shown to be a very effective antitumor. Doxorubicin induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Saidel,1 and jinming gao1,3 received november 7, 2003. Doxorubicin hydrochloride dox inhibits topoisomerase ii by intercalating between base pairs and by inducing strand breaks, resulting in the inhibition of nucleic acid and protein synthesis. Clinically significant interactions have been reported with inhibitors of cyp3a4, cyp2d6, andor pgp e. The most dangerous side effect of doxorubicin is dilated cardiomyopathy, leading to congestive heart failure. Patients receiving doxorubicin adriamycin potential nursing.
Cytochalasin d ready made solution c2618 datasheet. Doxorubicin hydrochloride is a dna intercalator and powerful cytotoxic agent. Doxorubicin is a major substrate of cytochrome p450 cyp3a4 and cyp2d6, and pglycoprotein pgp. Doxorubicin hydrochloride is an anthracycline antitumor antibiotic topoisomerase ii inhibitor, dna intercalator and powerful cytotoxic agent. The book begins by tracing the discovery and development of doxorubicin, highlighting factors such as a the involvement of organic chemistry at an early stage, which allowed the rapid identification of doxorubicin and ensured its prompt availability for the clinical trials. The water soluble anticancer agent dox is a hydroxy derivative of daunorubicin. Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of streptomyces peucetius var. Mixture relevant identified uses of the substance or mixture and uses advised against intended use. Doxorubicin hydrochloride, topoisomerase ii inhibitor ab120629. Doxorubicin hydrochloride 25316409 cayman chemical.
Doxorubicin treatment activates a zvadsensitive caspase, which causes deltapsim loss, caspase9 activity, and apoptosis in jurkat cells. To evaluate and compare the local pharmacokinetics of. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctors office. Doxorubicin hydrochloride adriamycin hydrochloride is an antitumour agent that has been formulated as a salt to achieve highe r water solubility. Specific neoplasia present decreased hepatic functioning decreased bone marrow or infiltration of marrow by tumor cells.
Breast cancer is a serious global health problem being the second most common of all cancers and by far the most frequent cancer amongst women. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Doxorubicin hydrochloride doxorubicin hydrochloride this product information is intended only for residents of the united states. Therefore, the ad7705ad7706 devices perform all signal conditioning and conversion for a 2channel or 3channel system. Pharmaceutical product used as antineoplastic details of the supplier of the safety data sheet 2. The devices can accept bipolar input ranges of 10 mv through 1. Material safety data sheet doxorubicin hcl adriamycin sc200923 hazard alert code key. Doxorubicin is given by injection into a vein common side effects include hair loss, bone marrow suppression. Doxorubin has been shown to inhibit dna synthesis in a dosedependent manner in mcf7. May cause eye, skin, or respiratory system irritation. Myocardial damage, including acute left ventricular failure, can occur with doxorubicin hydrochloride. Product and company identification product name doxorubicin product number 5927 identified uses for research use only ruo. Doxorubicin should be administered under the supervision of an experienced cancer chemotherapy physician cumulative doserelated cardiotoxicity may occur.
Sigmaaldrich offers a number of doxorubicin hydrochloride products. Each vial of doxorubicin ebewe contains 10 mg, 20 mg, 50 mg and 200 mg of doxorubicin hydrochloride as a solution 2 mgml. Doxorubicin is also used to treat hodgkin lymphoma, nonhodgkin lymphoma, and certain types of leukemia. It also contributes to the formation of free radicals for the disruption of membrane lipids and dna strands. Patients receiving doxorubicin adriamycin assessment prior to administration. Once doxorubicin hydrochloride associates with the dna groove, a covalent linkage forms between a dna base and the pendant sugar of the small molecule. Adriamycin doxorubicin hcl for injection, usp adriamycin doxorubicin hcl injection, usp for intravenous use only rx only warnings 1. It is soluble in water and slightly soluble in methanol. Hazards identification classification of the substance or mixture ghs classification. Comparison of doxorubicin concentration profiles in radiofrequencyablated rat livers from sustained and dualrelease plga millirods feng qian,1,4 nicholas stowe,2 gerald m. The drug should be administered under the supervision of an experienced cancer chemotherapy physician. The final concentration of dmso in the aqueous working medium should not exceed 0. View and buy high purity doxorubicin hydrochloride from tocris bioscience. Anticancer antibiotics details the development of doxorubicin as a widespectrum antitumor antibiotic.
Doxorubicin hydrochloride is an orangered, crystalline, hygroscopic powder that is soluble in water and slightly soluble in methanol. Used 2um doxorubicin hydrochloride to treat neonatal rat ventricular myocytes for 12 hr to 24 hr, see clear effect of cell damage. Pdf an overview of doxorubicin formulations in cancer therapy. Doxorubicin hydrochloride dox is an anthracycline antibiotic isolated from streptomyces peucetius var. Cytochalasin d ready made solution is supplied as a 5 mgml, 0. Doxorubicin hydrochloride is soluble in organic solvents such as ethanol and dmso, which should be purged with an inert gas. Gene expression alterations in doxorubicin resistant mcf7. The ad7705ad7706 devices, with a 3 v supply and a 1.
Doxorubicin, an anthracycline antibiotic, inhibits dna and rna synthesis in mammalian cells and has been shown to be a very effective anti tumor. Mtt 3 4,5dimethylthiazol2 yl2,5diphenyl tetrazolium bromide assay. Obtain complete health history including allergies, drug history and possible drug interactions. A stock solution may be made by dissolving the doxorubicin hydrochloride in the. Doxorubicin in combination with th302 in subjects with. Selected citations for doxorubicin hydrochloride include. Efficacy and cardiotoxicity of liposomal doxorubicinbased.
Doxorubicin hydrochloride for injection, usp doxorubicin hydrochloride injection, usp for intravenous use only warnings 1. Doxorubicin binds to nucleic acids by intercalating the dna double helix and stabilizing topoisomerase ii cleavage complexes, leading to dna strand breaks at specific doxorubicin induced sites 3. Regulatory information tsca status not on tsca inventory doxorubicin hydrochloride casno. When doxorubicin hydrochloride is administered in combination with other antitumour agents with overlapping toxicity, such as highdose i. Doxorubicin hydrochloride safety data sheet section 2. Mar 24, 2020 doxorubicin is used to treat different types of cancers that affect the breast, bladder, kidneys, ovaries, thyroid, stomach, lungs, bones, nerve tissues, joints, and soft tissues. Doxorubicin hcl adriamycin sc200923 hazard alert code key. Doxorubicin may also be used for purposes not listed in this. Lymphoma is especially sensitive to doxorubicin and the prognosis improves if the multiagent protocol includes doxorubicin. Doxorubicin hydrochloride is supplied as a crystalline solid. The rate of cardiomyopathy is dependent on its cumulative dose, with an incidence about 4% when the dose of doxorubicin is 500550 mgm 2, 18% when the dose is 551600 mgm 2 and 36% when the dose exceeds 600 mgm 2. Severe local tissue necrosis will occur if there is extravasation during administration see dosage and administration. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you.
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